Roshni Gill, Shivani Dwivedi, Sumit Narang

ABSTRACT

Background: Periodontitis is a chronic inflammatory condition that may influence systemic biomarkers, including renal-function markers such as serum creatinine(SCR). Previous studies have reported conflicting associations. This study aimed to investigate the effect of nonsurgical periodontal therapy (NSPT) on serum creatinine levels in systemically healthy individuals with moderate to severe chronic periodontitis. Materials & Methods: Thirty systemically healthy participants (aged 30–50 years) were recruited and divided into two groups: Group 1 (n=15) with moderate to severe chronic periodontitis and Group 2 (n=15) periodontally healthy controls. Clinical parameters (Plaque Index [PI], Gingival Index [GI], Probing Pocket Depth [PPD], Clinical Attachment Level [CAL]) and serum creatinine levels were recorded at baseline for both groups. Group 1 received NSPT (scaling and root planing), followed by reassessment at 90 days. Data were analysed using paired and independent t-tests (p<0.05). Results: At baseline, the periodontitis group showed significantly higher serum creatinine (0.6920 ± 0.07163 mg/dL) compared to controls (0.6427 ± 0.03674 mg/dL; p=0.025). PPD and CAL were also significantly higher in Group 1 (p<0.001). After 90 days of NSPT, periodontal parameters improved significantly (p<0.05), and serum creatinine decreased significantly (from 0.6920 ± 0.07163 to 0.6620 ± 0.04346 mg/dL; paired t-test, p=0.004). Conclusion: Serum creatinine is elevated in systemically healthy individuals with moderate to severe periodontitis and is associated with periodontal severity. Short-term NSPT significantly reduces serum creatinine levels alongside periodontal improvements.